The Oncometabolite 2-Hydroxyglutarate Is Upregulated in Post-Prostatectomy PSA Recurrence of Prostate Cancer: A Metabolomic Analysis.

8, 9 (High, n = 21) yielded 120 metabolites at p < 0.05 and of these 12 were highly significant (adj. p < 0.05) ( Table 2 ).

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Among the lipids, there was a clear trend of lower lipid levels in case of higher Gleason score [PC (p-36:1) or PC (o-36:2), PC 38:2e, Cer (d41:1)] ( Figure 5 A–C), with the exception being LPC (18:1) ( Figure 5 D).

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Significantly, ethnicity appeared to have a fairly significant effect on certain lipids in the prostate tissue, while differentially expressed triglycerides were seen in the prostate in patients with extreme BMI (≥40).

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