Passive physical barrier modulates UVB-induced METosis-related MPO expression and activity, 25-hydroxyvitamin D3-1alpha-hydroxylase, and the shift of tissue-resident macrophages toward M1-associated iNOS.

Front Immunol · 2025 · PMC12390812 · PMID 40895555

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did not reach statistical significanceno p-value reported

3.2 UVB increases NO production, H 2 O 2 , METosis-related MPO expression, and HOCl levels, with a moderate effect on phagocytosis, while the simulated barrier downregulates HOCl levels As shown in Figure 4 , UVB exposure led to a minimal increase in phagocytic activity in PRMφs, and did not reach statistical significance.

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