Integrated Systems Biology Identifies Disruptions in Mitochondrial Function and Metabolism as Key Contributors to HFpEF.

JACC Basic Transl Sci · 2025 · PMC12390939 · PMID 40818383

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did not reach statistical significanceno p-value reported

In the presence of pyruvate and malate (complex I) or succinate and rotenone (complex II), mitochondria from ZSF1-lean and -obese hearts showed a significant reduction in state 3 respiration ( Figures 7C and 7E ); fatty acid supported state 3 respiration (palmitoyl- l -carnitine) also trended lower but did not reach statistical significance ( Figure 7G ).

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