Gut microbiota-derived metabolite trimethylamine N-oxide alters the host epigenome through inhibition of S-adenosylhomocysteine hydrolase.

J Biol Chem · 2025 · PMC12390942 · PMID 40716746

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a clear trendno p-value reported

Several methylation marks, including H2A3 K15me1, H3 K27me1, H3 K27me1K36me1/2, H3 K36me3, and H3 K9me1 showed a clear trend toward reduction.

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