Comparative analysis of first-generation epidermal growth factor receptor inhibitors combined with chemotherapy versus third-generation epidermal growth factor receptor inhibitors in the treatment of advanced non-small cell lung cancer: a systematic review and meta-analysis.

Front Pharmacol · 2025 · PMC12391186 · PMID 40894225

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did not reach statistical significanceno p-value reported

Conversely, 1 st -G TKIs combined with chemotherapy produced a numerically lower risk of death than 3 rd -G TKIs (OS: HR 0.78, 95% CI 0.56–1.07; P = 0.122), but this difference did not reach statistical significance ( Figure 3A ).

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