Association between polygenic risk and survival in breast cancer patients.

Three additional associations were borderline significant after multiple testing: a PRS for high blood pressure was associated with renal cell carcinoma (OR = 1.20, p = 2.10 × 10 –4 ), a PRS for deep vein thrombosis had the most significant association with pancreatic cancer (OR = 1.13, p = 1.10 × 10 –4 ), and a PRS for peripheral artery disease was associated with lower risk for glioma (OR = 0.90, p = 2.10 × 10 –5 ; note because other cancers were used as a control this could alternatively be interpreted as high risk for non-glioma cancers.

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An additional fifteen PRS were nominally significant, including four breast cancer-related PRS which were all associated with longer survival with the sequencing index date (Supplementary Table 1).

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