Advancing paroxetine treatment in depression: predicting remission and plasma concentration, and validating and updating therapeutic reference ranges.

For the comparison across three TRR standards, patients with Css within 20.8–52.5 ng/ml demonstrated higher remission rates and lower ADR rates compared to those with Css within 20–65 ng/ml or 31.55–52.5 ng/ml, though the differences did not reach statistical significance (Fig. 3d, e , Supplementary table 9 , Fig. 2 , and Fig. 4 ).

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