Multi-ancestry meta-analysis identifies genetic modifiers of age-at-onset of Alzheimer's disease at known and novel loci.

Four signals had both nominally significant evidence of heterogeneity and opposing directions of effect (5q33.3 ADRA1B , 11q13.1 CATSPERZ , 17p11.2 FBXW10 , 18p11.21 LDLRAD4 ). 3.2.1 Evidence supporting loci with significant heterogeneity We investigated the support for each genome‐wide significant locus in the meta‐analysis with strong evidence for heterogeneity and effect size estimates in opposite directions between the discovery and replication data sets.

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