The simultaneous activation of μ- and δ-opioid receptors by (-)-2<i>S</i>-LP2 rescues allodynia with the contribution of TGF-β1 signaling in a rat chronic constriction injury model.

4 B–E, §§p < 0.01), and NTD + NLX group alone or in combination with (−)-2S-LP2 showed a trend toward decrease, although not statistically significant, if compared to CCI+(−)-2 S -LP2 animals, suggesting that (−)-2 S -LP2 can exerts its antiallodynic activity with the contribution of the TGF-β1 pathway via co-targeting MOR/DOR. 4.

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