Whole genome transcriptional analysis of intestinal biopsies and blood cells indicate genes involved in antioxidant defense systems, amino acid metabolism and antigen presentation in the pathogenesis of celiac disease.

Results Differential expression Overall, 7565 genes were differentially expressed (nominally significant p < 0.05) in small intestinal biopsies between cases with a-CD and controls, and 5244 genes remained differentially expressed after adjusting for multiple comparisons.

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Some of these were also significant, or borderline significant, in the comparison between p-CD versus control or t-CD versus control, indicating a difference in individuals with both a-CD, p-CD, and t-CD versus controls.

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