Dissecting the Causal Effects of Helicobacter pylori Serotypes on Gastric Cancer Risk: A Two-Sample Mendelian Randomization Study.

Cureus · 2025 · PMC12398672 · PMID 40896015

Europe PMC DOI

hedged sentences

0.0770

closest p · 1.5× alpha

0.0770

boldest claim

The sentences

did not reach statistical significanceP = 0.077so close (0.05 < p ≤ 0.1)

pylori -GC pathway, accounting for a substantial portion of the total effect (estimated at 47.0%), though this finding did not reach statistical significance ( P = 0.077).

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at the margin of statistical significanceP = 0.077so close (0.05 < p ≤ 0.1)

The indirect effect via TNFSF18 was at the margin of statistical significance (β indirect : 0.054, 95% CI: -0.006 to 0.115; OR: 1.06, 95% CI: 0.99-1.12; P = 0.077) and was estimated to account for 47.0% of the total causal effect, indicating a potential role for the GITR-GITRL signaling pathway in H. pylori -driven carcinogenesis.

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at the margin of significanceno p-value reported

Although the statistical evidence for this mediation pathway was at the margin of significance, its biological coherence and the substantial proportion of the total effect it potentially explains (47%) make it a compelling, hypothesis-generating finding that warrants further experimental investigation.

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