Mapping iron content and white matter integrity in the anterior thalamic radiations across Huntington's disease stages.

3.2 Clinical correlates 3.2.1 Relationship between white matter ATR microstructure and iron levels with neuropsychological assessments in gene carriers Reported correlations include those statistically significant with an adjusted p-value (p-adj) < 0.05, as well as those showing a statistical trend, defined as an uncorrected p-value (p-unc) < 0.05 but a non-significant adjusted p-value (p-adj < 0.10).

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In the left ATR, for controls, R2* was weakly to moderately negatively correlated with FA (r = –0.129, p-adj < 0.001) and RD (r = –0.100, p-adj = 0.011), and showed a trend-level negative association with AD (r = –0.072, p-unc = 0.026, p-adj = 0.077), while no significant correlation was found with MD (r = 0.046, p-adj = 0.301).

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