Optimizing anisotropic margins in single-isocenter multiple brain metastases radiosurgery using regressor strategies: A multi-institutional validation study.

J Appl Clin Med Phys · 2025 · PMC12398955 · PMID 40886139

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25 , 63 A study showed a trend of V12 associated with increased toxicity risks, and a high rate ( ∼ 50%) of toxicity with V12 >10 cm 3 . 36 , 64 However, these reports established values considering mainly SRS plans in machines like Gamma Knife, where the considerations may differ from a linear accelerator.

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