Patent Foramen Ovale Closure in Older Patients With Cryptogenic Stroke: Current Evidence and Next Steps.

Struct Heart · 2025 · PMC12399247 · PMID 40894374

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did not reach statistical significanceno p-value reported

While the difference in recurrent ischemic stroke incidence did not reach statistical significance (HR: 0.58; 95% CI: 0.30-1.12; p = 0.107), a statistically significant reduction in the composite outcome of ischemic stroke or TIA was observed in the PFO closure group (HR: 0.45; 95% CI: 0.24-0.84; p = 0.012).

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