Cytogenetic abnormalities in polycythemia vera: phenotypic correlates and prognostic relevance in 669 informative cases.

14 Similarly, a prior Mayo Clinic study documented new cytogenetic abnormalities in 25% of patients with PV and change in karyotype from “normal” to “abnormal”, in the absence of overt disease transformation, showed a trend for adverse survival. 15 Collectively, these findings strengthen the argument for conducting karyotypic analysis at the time of diagnosis but also underscore the case for follow-up reassessment of karyotype to ensure continued surveillance.

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