Impact of stopping Tenofovir disoproxil fumarate at various times on elevated postpartum ALT levels and breastfeeding in pregnant women with chronic hepatitis B: a prospective observational cohort study.

BMC Pregnancy Childbirth · 2025 · PMC12400636 · PMID 40887644

Europe PMC DOI

hedged sentence

0.0620

closest p · 1.2× alpha

0.0620

boldest claim

The sentences

did not reach statistical significanceP = 0.062so close (0.05 < p ≤ 0.1)

Furthermore, while the overall comparison between immediate discontinuation (Group A) and later withdrawal groups (Groups B and C) did not reach statistical significance, the trend toward higher ALT exacerbation rates in Group A ( P = 0.062) highlights potential risks associated with early discontinuation, and prolonged TDF therapy may provide increasing protection against severe liver inflammation.

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