Association between impaired lung function and risk of spondyloarthritis: a cross-sectional study in the UK Biobank.

While the PRISm subgroup within PsA (OR (95% CI), 1.165 (1.006–1.350)) maintained a measurable association with lung impairment, the overall correlation between pulmonary dysfunction and pSpA incidence did not reach statistical significance (OR (95% CI), 1.115 (0.974–1.276) p = 0.114; Supplemental Tables 3–6 ).

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55 , 56 Emerging research indicates that obstructive lung diseases may be significant pulmonary manifestations of rheumatic diseases, while the risk of SpA is more associated with a restrictive spirometry pattern, such as PRISm, and absence of increased risk in COPD. 57 This differential susceptibility might explain: (1) Disease stage relevance: PRISm represents an early inflammatory phase characterized by mild restrictive ventilatory impairment (FVC <80% predicted), often preceding overt COPD.

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