Insights from Tissue Inhibitor of Metalloproteinase-2 Genotypes to Decipher the Genetic Architecture of Childhood Acute Lymphocytic Leukemia Risk.

Cancer Genomics Proteomics · 2025 · PMC12402721 · PMID 40883020

Europe PMC DOI

hedged sentences

0.0744

closest p · 1.5× alpha

0.4488

boldest claim

The sentences

borderline significantp =0.0744so close (0.05 < p ≤ 0.1)

In the dominant model, individuals with CG or CC genotypes showed a borderline significant association with increased ALL risk relative to GG carriers (OR=1.42, 95%CI=0.98-2.06, p =0.0744).

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a significant trendp =0.4488not close (p > 0.1)

A significant trend in genotype distribution was observed among participants aged 3.5 years or younger ( p for trend=0.0228), but not in the older age group ( p =0.4488).

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