Missense variant analysis in the TRPV1 ARD reveals the unexpected functional significance of a methionine.

Although there was considerable variability in the data, we observed a clear trend where M308I currents increased more steeply than those of WT or M308V channels ( Fig 2C ).

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When ranked by their fractional SASA scores, the amino acids of the ARD show an increasing trend in the types of amino acids coded by missense variant sequences found in the human population (yellow bar plot, Fig 1A and S1 Fig ).

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