showed a trendp = 0.129
While the control group showed a trend of negative correlation between the cortical thickness in this region and the DST score ( p = 0.129), the MHE showed a flat spread for DST score ( p = 0.282) and the OHE group showed a significant positive correlation with the DST score ( p < 0.001), which may be suggestive of a gradient of neuronal alteration in the process of disease progression (More details in supplementary materials, Fig.