Thiazole substitution of a labile amide bond-a new option toward antiplasmodial pantothenamide-mimics.

Instead, the phenyl group may be favored (as in 2e ) with a slightly lower IC 50 (0.51 μM) compared to those of 1a (0.77 μM) and 1e (0.77 μM), although these did not reach statistical significance at the P ≤ 0.05 level ( P = 0.059 and 0.052, respectively).

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