Real-world study on fluoropyrimidine-related toxicity outcomes in cancer patients with select DPYD variant alleles that received DPYD genotype-guided dosing.

Int J Cancer · 2025 · PMC12407033 · PMID 40536615

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a clear trendno p-value reported

15 , 26 , 29 , 30 , 31 , 33 We found a clear trend in fluoropyrimidine tolerance differences between DPYD variant genotypes, with c.1236G>A variant carriers seeming to be less prone to experience severe toxicity than DPYD*2A and c.2846A>T variant carriers.

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