Time-resolved miRNA-mRNA integrated analysis reveals the miRNA-mRNA networks underlying plasma membrane damage-dependent senescence and DNA damage response-dependent senescence in WI-38 normal human fibroblasts.

RNA Biol · 2025 · PMC12407646 · PMID 40843545

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did not reach statistical significanceno p-value reported

The experimental results revealed that the expression of miR-155-5p target mRNAs ( AMIGO1 , CCND2 , CYB5D2 , FAM171A2 , and MXI1 ) exhibited downregulation in response to the miR-155-5p mimic and upregulation when exposed to the miR-155-5p inhibitor; however, these changes did not reach statistical significance ( Figure 6F ).

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