Predictive value of patent foramen ovale diameter for cryptogenic stroke and age-related differences.

NCS) helps account for why PFO diameter did not reach statistical significance in multivariate regression for this group, despite ROC analysis suggesting potential predictive capacity (AUC = 0.777, cut-off = 1.75 mm), highlighting the need for caution in interpreting results here, even as large RLS showed a trend toward significance (OR = 7.576, P = 0.099).

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For the younger subgroup, the power was <70%, which may explain why PFO diameter did not reach statistical significance in the regression analysis for this subgroup (despite the OR suggesting a potential association); this indicates that the smaller sample size in the younger patient subgroup may have limited the ability to detect effects, requiring cautious interpretation.

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