Innate immune response to AAV-based gene therapy vectors: Mechanisms of complement activation and cytokine release.

Mol Ther Methods Clin Dev · 2025 · PMC12409308 · PMID 40917687

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highly significantno p-value reported

After 24 h, both CD4 + and CD8 + T cells showed a highly significant increase in the expression of genes induced by IFN type I ( IFI6, ISG15, MX1, MX2, HERC5, TRIM22, IFI16, IFIT1, and OAS2 ) and of other genes involved in the immune response ( STAT1, XAF1, RNF213, and SAMD9 ).

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did not reach statistical significanceno p-value reported

This AAV genome-dependent release was clearly observed in the case of IFN-ɑ, even though it did not reach statistical significance due to the high donor-dependent variability.

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