Alternating 2D and 3D culture reduces cell size and extends the lifespan of placenta-derived mesenchymal stem cells.

Front Bioeng Biotechnol · 2025 · PMC12411557 · PMID 40918436

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a clear trendno p-value reported

When these MSCs were cultured over multiple passages, a clear trend of increasing cell size with successive passages was observed ( Figure 1E ).

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