GALNT7 Stratifies dMMR/MSI Colorectal Cancer into Distinct Molecular Subsets Associated with Prognosis and PD-L1 Expression.

Cancer Res Commun · 2025 · PMC12412012 · PMID 40824763

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0.0692

closest p · 1.4× alpha

0.1677

boldest claim

The sentences

a nonsignificant trendP = 0.0692so close (0.05 < p ≤ 0.1)

We next conducted survival analysis, and GALNT7-High colorectal cancers showed a nonsignificant trend toward favorable RFS compared with GALNT7-Low colorectal cancers (n = 453; P = 0.0692; HR = 0.57; 95% CI, 0.29–1.02; Supplementary Fig.

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marginal significanceP = 0.079so close (0.05 < p ≤ 0.1)

Moreover, multivariable analysis of MSI colorectal cancers demonstrated that GALNT7 had significant prognostic value in the AC-ICAM MSI (HR = 0.20; 95% CI, 0.03–0.84; P = 0.047) and GSE39582 MSI (HR = 0.09; 95% CI, 0.01–0.52; P = 0.027) cohorts, independent of other clinical covariates, whereas it showed marginal significance in TCGA MSI cohort (HR = 0.24; 95% CI, 0.04–1.01; P = 0.079; Supplementary Table S4).

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did not reach statistical significanceP = 0.1677not close (p > 0.1)

A similar prognostic trend was observed in GSE39582 , although it did not reach statistical significance ( P = 0.1677, Fig. 1F ).

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