Barely Significant
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Do Super-hydrophilic Surfaces Affect Implant Primary Stability in the Early Healing Phase of Osseointegration? A Systematic Review with Metanalysis.

Oral Health Prev Dent · 2025 · PMC12412763 · PMID 40853239

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a favorable trendno p-value reported
Due to the presence of confounding factors (stability mainly due to the cortical component) in this early healing phase, a significant advantage in the use of bioactive surfaces is not detectable, even if a favorable trend is apparent.

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a positive trendno p-value reported
The results of the ISQ extrapolated from the literature analyzed in this review showed a positive trend in favor of bioactive implants beginning at one month from insertion, although this was not statistically significant.

also in 6,068 other papers

Analyzing the data related to marginal bone loss, the results showed a slight advantage in favor of bioactive implants, although this difference did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.