Genetically diverse mice exhibit divergent domain-specific, sex-dependent behavioral outcomes following exposure to early life stress.

PLoS One · 2025 · PMC12412987 · PMID 40911572

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.1700

boldest claim

The sentences

a trend toward significancep = .06so close (0.05 < p ≤ 0.1)

In DO mice, there was a trend toward significance for the interaction between all three factors (stress × sex × stimuli, F(1,95)=3.62, p = .06) because MSEW females spent less time in the zones that had been paired with social stimuli compared to other groups.

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did not reach statistical significancep = .17not close (p > 0.1)

Finally, female MSEW mice also exhibited greater latency to enter the arms than their NS counterparts (p = .05); this trend was true for male MSEW mice but the difference did not reach statistical significance (p = .17; Fig 3C ).

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