Multimodal neuroimaging unveils basal forebrain-limbic system circuit dysregulation in cognitive impairment with depression: a pathway to early diagnosis and intervention.

Although the association between gray matter volume and MoCA scores did not reach statistical significance (β = 0.224, p = 0.09), the indirect effect of FW on cognition via VBM (FW → VBM → MoCA) was significant (β_indirect = –0.071, p = 0.030). 3.6 Classification of NC, CI-nD, and CI-D groups In the present study, a total of 529 subjects from the BEC cohort, who met rigorous criteria for data completeness and homogeneity, were included in the construction of classification models.

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