Inductive coupled plasma optical emission spectrometry (ICP-OES) was used to measure TS-Mg/Sr hydrogels with different divalent metal salt concentrations (Mg 2+ 3 mM, Mg 2+ 2 mM; Sr 2+ 1 mM, Mg 2+ 1.5 mM; Sr 2+ 1.5 mM, Mg 2+ 1 mM; Sr 2+ 2 mM, and Sr 2+ 3 mM) analysis showed that the concentration of Mg and Sr ions released from each group showed a trend of first-order kinetic sustained release over the incubation time of 30 days ( Figure 1 C).
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Sustained Mg/Sr ion delivery from injectable silk fibroin hydrogels drives SCAP osteogenic differentiation.
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