Effect of Combined Renal Denervation and Pulmonary Vein Isolation on Atrial Fibrillation: A Systematic Meta-Analysis.

Of note, freedom from AF recurrence at 12 and 24 months after catheter ablation in the RDN + AF group and the PVI-only group did not reach statistical significance in the recently published RDN + AF study. 13 Although the exact mechanism behind the antiarrhythmic effects of RDN remains elusive, it was proposed that autonomic nervous system modulation plays a central role. 30 An increase in the activation of SNS was related to the promotion of atrial arrhythmia genesis 31 by exacerbating left atrial structural modifications and hence electrical remodeling into AF.

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