Network analysis of NRG1 variants of uncertain significance (VUSes) in advanced non-small-cell lung cancer and their prognostic role in EGFR-mutant patients treated with first-line osimertinib.

ESMO Open · 2025 · PMC12418825 · PMID 40885102

Europe PMC DOI

hedged sentences

0.0719

closest p · 1.4× alpha

0.1335

boldest claim

The sentences

borderline significantP = 0.0719so close (0.05 < p ≤ 0.1)

NRG1 mutational status was the only molecular variable to confirm significant prognostic value for PFS ( P = 0.0104) and to reach borderline significant association for OS ( P = 0.0719).

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failed to reach statistical significanceP = 0.1335not close (p > 0.1)

Among molecular variables, EGFR type of mutation failed to reach statistical significance for both PFS ( P = 0.1335) and OS ( P = 0.0619), despite a trend toward association being confirmed.

also in 6,035 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.