Immunoprofiling at an Institutional Scale Reveals That High Numbers of Intratumoral CD8<sup>+</sup> and PD-1<sup>+</sup> Cells Predict Superior Patient Survival Across Major Cancer Types Independent of Major Risk Factors.

JCO Precis Oncol · 2025 · PMC12419029 · PMID 40906987

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

approached significanceP = .06so close (0.05 < p ≤ 0.1)

Patients with TN BRCA with high CD8 + PD-1 + cell counts had a lower risk that approached significance ( P = .06; Fig 5 ).

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highly significantno p-value reported

Moreover, they remained highly significant in predicting patient survival in Cox models accounting for major clinical risk factors.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Immunoprofiling at an Institutional Scale Reveals That High Numbers of Intratumoral CD8&lt;sup&gt;+&lt;/sup&gt; and PD-1&lt;sup&gt;+&lt;/sup&gt; Cells Predict Superior Patient Survival Across Major Cancer Types Independent of Major Risk Factors.

The sentences

Immunoprofiling at an Institutional Scale Reveals That High Numbers of Intratumoral CD8<sup>+</sup> and PD-1<sup>+</sup> Cells Predict Superior Patient Survival Across Major Cancer Types Independent of Major Risk Factors.