Mice harboring the obesity-associated SNP rs1421085 exhibit increased body weight and reveal an IRX3 neuronal circuit regulating body weight.

Finally, given rs1421085's strong association with sweet taste preference [ 11 ], we subjected OA-SNP rs142/rs142 mice and OA-SNP +/+ mice to a two-bottle choice assay and observed a strong trend towards increased sucrose intake in rs1421085 harboring mice ( Supplemental Fig. 1M ).

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