Western blot assay also showed a trend in which the KLHL8 protein level was highest in metaphase I (MI) oocytes, with the abundance decreasing during meiotic maturation and becoming only mildly detectable in 2 pronuclear (2PN) embryos (Figs. 1B and EV1B ).
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The E3 ubiquitin ligase adaptor KLHL8 targets ZAR1 to regulate maternal mRNA degradation in oocytes.
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