An early surge of norepinephrine along brainstem pathways drives sensory-evoked awakening.

Sci Adv · 2025 · PMC12422181 · PMID 40929279

Europe PMC DOI

hedged sentences

0.0002

closest p · 0.0× alpha

0.0600

boldest claim

The sentences

highly significantP = 1.6 × 10 −4actually significant

This model proved to be highly significant (χ 2 compared to the constant model: 17.51, P = 1.6 × 10 −4 ; table S6).

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showed a trendP = 0.06so close (0.05 < p ≤ 0.1)

PRN silencing showed a trend ( P = 0.06, Tukey-Kramer post hoc test) for reduced awakening probability, while silencing the BF alone was not significantly different compared to sham stimulation ( P = 0.14, Tukey-Kramer post hoc test).

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