Predictors of risk of secondary progression in multiple sclerosis.

Ther Adv Neurol Disord · 2025 · PMC12423534 · PMID 40951543

Europe PMC DOI

hedged sentence

0.0760

closest p · 1.5× alpha

0.0760

boldest claim

The sentences

did not reach statistical significancep = 0.076so close (0.05 < p ≤ 0.1)

The median (IQR) sNfL concentration in all patients with MS was 8.3 (7.2–10.7) pg/ml with slightly higher sNfL concentrations in SPMS convertors, but this difference did not reach statistical significance (11 (8.4–15) vs 8.0 (6.9–8.8) pg/ml; p = 0.076) ( Figure 4(b) ).

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