β-Lactam Adjunctive Therapy Compared to Vancomycin or Daptomycin Monotherapy in Adult Patients With Methicillin-Resistant <i>Staphylococcus aureus</i> Bacteremia: An Update Systematic Review, Meta-Analysis, and Trial Sequential Analysis.

In our subgroup analysis, we observed that DAP + BLs appeared to decrease all-cause mortality; however, this finding did not reach statistical significance (RR = 0.65, p =0.15).

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However, these microbiological advantages must be weighed against two concerning findings: a nonsignificant trend toward increased Clostridium difficile infection (CDI) risk and elevated mortality signals in high-quality subgroup analyses.

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