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Claudin18.2 defines a prognostically distinct subgroup of intrahepatic cholangiocarcinoma via CD8<sup>+</sup> T-cell exclusion.

Front Oncol · 2025 · PMC12425741 · PMID 40951359

Europe PMCDOI
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0.1200
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0.1200
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showed a trendP = 0.12not close (p > 0.1)
Single-sample gene set enrichment analysis (ssGSEA) analysis revealed an inverse correlation between CLDN18 expression and CD8 + T cells ( P = 0.012), while IHC showed a trend toward negative correlation between CLDN18.2 expression and CD8 + TILs density ( P = 0.12).

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