Telomere attrition becomes an instrument for clonal selection in aging hematopoiesis and leukemogenesis.

Nat Genet · 2025 · PMC12425810 · PMID 40877435

Europe PMC DOI

hedged sentences

0.0780

closest p · 1.6× alpha

0.1500

boldest claim

The sentences

a nonsignificant trendP = 0.078so close (0.05 < p ≤ 0.1)

Furthermore, analysis of hematopoietic phylogenies revealed a nonsignificant trend towards longer telomeres in the sole U2AF1 -Q157R mutant clade in our cohort ( P = 0.078; Fig. 3b ), with the difference in telomere lengths closely approaching statistical significance ( P = 0.053) when this clade was compared to ancestrally related colonies, despite rapid recent clonal expansion after U2AF1 -Q157R acquisition (Supplementary Note 1 and Extended Data Fig. 5 ).

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did not reach statistical significanceP = 0.15not close (p > 0.1)

A similar trend was seen with U2AF1 -CH, but did not reach statistical significance (false discovery rate (FDR)-adjusted P = 0.15).

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