Systemic lipid and glucose modulation differentially affects cognitive function and neuroinflammation in a mouse model of Alzheimer's disease.

Front Neurosci · 2025 · PMC12426080 · PMID 40948809

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In contrast, 5xFAD mice treated with Alirocumab exhibited a statistically significant higher LTP than the control group of 5xFAD mice, comparable to the values obtained with the WT, while 5xFAD mice treated with Gliclazide showed a trend for but not a statistically significant increase in the LTP compared to control 5xFAD ( Figure 2f ).

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