Direct and indirect effects of spliceosome disruption compromise gene regulation by nonsense-mediated mRNA decay.

Depletion of all 11 catalytic spliceosome components caused a highly significant upregulation of PTC-containing transcripts, whereas in the case of early components, either the effect on NMD substrates was insignificant (SNRNPC and PRPF6) or only moderately significant (SNRNP70 and PRPF3) ( Figure 2 and S2).

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