A Comprehensive Review of Fluid Resuscitation Strategies in Traumatic Brain Injury.

J Clin Med · 2025 · PMC12428941 · PMID 40944047

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did not reach statistical significanceno p-value reported

While the CPPopt group showed lower mortality and better recovery, these differences did not reach statistical significance—likely due to the fact that COGiTATE was designed as a feasibility trial [ 141 ].

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