A Novel Scoring System for the Administration of an IgM- and IgA-Enriched Intravenous Immunoglobulin Preparation: The SORRISO Score.

The last two factors exhibited highly significant differences between the coordinating center and other hospitals ( p < 0.001).

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The most significant differences among the different centers include the age of the patients ( p = 0.009), the sites of infection ( p < 0.001), and the proportion of ICU admissions for medical or surgical pathology ( p = 0.058), with a borderline significant value, whereas the severity of the cases did not differ among the centers ( p = 0.799); the lack of precise enrollment criteria likely accounted for these variations.

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Statistical Analysis with Kaplan–Meier Curves for rTo-PIRO Criteria with p-Values Below 0.05 or Almost Significant Yet Included in the SORRISO Score Appendix A.2.

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In the last phase of this study, all the statistically significant or near-significant variables demonstrated in this revised TO-PIRO Score (rTO-PIRO) were analyzed and used to build up the SORRISO Score.

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