Myristic Acid Remodels Sphingolipid Metabolism via Dual Pathways: Canonical d18-Sphingolipid Regulation and Non-Canonical d16-Sphingolipid Synthesis.

Nutrients · 2025 · PMC12429915 · PMID 40944268

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While d18:0-DHHexCer exhibited significant downregulation of C16:0 and C20:0 side chains ( Figure 3 C), d18:1-HexCer showed a marked increase in the N -acyl C14:0 content accompanied by a clear trend toward elevated levels of C16:0, C18:0, C20:0, and C22:0 ( Figure 3 D), alongside decreases in C24:0 and C24:1.

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