Investigating Causal Links between Metabolite Profiles and Ulcerative Colitis: A Bidirectional Mendelian Randomization Study.

Sensitivity analyses’ results In addition to the IVW method, the WM method also showed a marginally positive significant association between total lipids in S.HDL.L and UC (OR = 1.201, 95% CI: 0.994–1.451, P = 0.052) [ Table 2 ], although this association did not reach statistical significance at a Bonferroni-corrected threshold ( P < 9.94 × 10 −5 ).

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Since we detected no significant evidence of horizontal pleiotropy ( P > 0.05), the marginally significant positive association between total lipids in S.HDL.L and UC is less likely to be driven by pleiotropy or other major sources of bias.

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