Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium.

Elife · 2025 · PMC12431772 · PMID 40938325

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Interestingly, IR41-transduced mice showed a trend toward higher cardiac viral genome loads than AAV9-transduced mice upon sham injury, indicating that IR41 might increase tropism in uninjured hearts, but its effects will be greatest when delivered to injured hearts ( Figure 5D ).

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