Rethinking surrogate endpoints in metastatic colorectal cancer: counting chickens only when they hatch.

J Gastrointest Oncol · 2025 · PMC12432952 · PMID 40950350

Europe PMC DOI

hedged sentence

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

did not reach statistical significanceP=0.08so close (0.05 < p ≤ 0.1)

46% with doublet chemotherapy, although this difference did not reach statistical significance (P=0.08) ( 3 ).

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