Diabetic Peripheral Neuropathy: Pathophysiology and New Insights into the Mechanism of Action of High-Concentration Topical Capsaicin.

25 A meta-analysis of 17 randomized studies showed that improved glycemic control can reduce the risk of development of clinical neuropathy in type 1 diabetes; in type 2 diabetes, however, improved glycemic control numerically reduced the risk but this did not reach statistical significance. 27 In type 2 diabetes, the progression of the pathology caused by prolonged hyperglycemia and other metabolic changes is not reversible without substantial changes to diet and lifestyle. 25 , 28 , 29 The pathology of DPN in type 2 diabetes is not fully understood, but involves metabolic imbalances and microvascular complications, ultimately causing neural damage and an altered response to pain and sensory stimulation.

also in 111,027 other papers